中文 
别名:AKT; AKT1 kinase; kinase Akt1; RAC; RAC-PK-alpha应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl
| Description |
|---|
| General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at ‘Ser-939’ and ‘Thr-1462’, thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Nguyen le XT, Mitchell BS (2013) Proc Natl Acad Sci U S A 110, 20681-6 Ponce DP, et al. (2011) Mol Cell Biochem 356, 127-32 Siddiqui-Jain A, et al. (2010) Cancer Res 70, 10288-98 |
| Specification | |
|---|---|
| Aliases | AKT; AKT1 kinase; kinase Akt1; RAC; RAC-PK-alpha |
| Entrez GeneID | 207; |
| Swissprot | P31749 |
| WB Predicted band size | 65kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of serine129(D-N-S(p)-G-A) derived from Human Akt . |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
 |
Western blot analysis of extracts from A549 cells treated with PMA using Phospho-Akt (Ser129) antibody P40554.The lane on the right is treated with the antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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