中文 
别名:RN49018应用:IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2), infantile onset ascending hereditary spastic paralysis (IAHSP) and a form of complicated hereditary spastic paraplegia (cHSP). The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein, which is associated with small, punctate membrane structures. Therefore Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal like protein (ALS2CL) also modulates Rab5 activity. |
| Specification | |
|---|---|
| Aliases | RN49018 |
| Entrez GeneID | 259173; |
| Swissprot | Q60I27 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ALS2CL |
| Formulation | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Application | |
|---|---|
| IHC | 1/ 20-100 |
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The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ALS2CL Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200) |
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The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ALS2CL Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200) |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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