Rabbit Polyclonal Antibody to Amyloid β A4 (Phospho-Thr743/668)

包装: 1G|100G|500G|1KG|100KG

现货支持定制

QQ咨询
| 微信咨询

400-880-2824

满200元免运费
正品保障提供发票
现货闪电当时发货

别名:A4; AD1; APP; APPI; Beta-amyloid protein 42
应用:WB,IHC,ICC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Ming-Sum Lee J. Cell Biol., Oct 2003; 163: 83Tadashi Nakaya and Toshiharu Suzuki Genes Cells, Jun 2006; 11: 633 – 645Keun-A Chang, Mol. Cell. Biol., Jun 2006; 26: 4327 篓C 4338Thor D. Stein J. Neurosci., Sep 2004; 24: 7707 – 7717

Description

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Ming-Sum Lee J. Cell Biol., Oct 2003; 163: 83Tadashi Nakaya and Toshiharu Suzuki Genes Cells, Jun 2006; 11: 633 – 645Keun-A Chang, Mol. Cell. Biol., Jun 2006; 26: 4327 篓C 4338Thor D. Stein J. Neurosci., Sep 2004; 24: 7707 – 7717

Specification
Aliases	A4; AD1; APP; APPI; Beta-amyloid protein 42
Entrez GeneID	351;
Swissprot	P05067
WB Predicted band size	140kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of threonine743 /668 (A-V-T(p)-P-E) derived from Human Amyloid β A4.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/100-1/200

	Western blot analysis of extracts from cos-7 cells (Lane 2), using Amyloid β A4 (Phospho-Thr743/668) Antibody P40365. The lane on the left is treated with antigen-specific peptide.
	Immunofluorescence staining of methanol-fixed HeLa cells using Amyloid β A4 (phospho-Thr743/668) Antibody P40365.
	Immunohistochemical analysis of paraffin-embedded human brain tissue using Amyloid β; A4 (phospho-Thr743/668) antibody P40365 (left)or the same antibody preincubated with blocking peptide (right).