Rabbit Polyclonal Antibody to Androgen Receptor (Phospho-Tyr363)

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别名:ANDR; Androgen receptor; Dihydrotestosterone receptor; NR3C4;
应用:WB
反应种属:Human,Mouse
规格：50μl/100μl

Description
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.Lubahn D.B., Mol. Endocrinol. 2:1265-1275(1988)Chang C., Proc. Natl. Acad. Sci. U.S.A. 85:7211-7215(1988)Tilley W.D., Proc. Natl. Acad. Sci. U.S.A. 86:327-331(1989).

Description

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.Lubahn D.B., Mol. Endocrinol. 2:1265-1275(1988)Chang C., Proc. Natl. Acad. Sci. U.S.A. 85:7211-7215(1988)Tilley W.D., Proc. Natl. Acad. Sci. U.S.A. 86:327-331(1989).

Specification
Aliases	ANDR; Androgen receptor; Dihydrotestosterone receptor; NR3C4;
Entrez GeneID	367;
Swissprot	P10275
WB Predicted band size	85kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of tyrosine 363 (D-Y-Y(p)-N-F) derived from Human Androgen Receptor.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000

Western blot analysis of extracts from HuvEc cells (Lane 2), COS7 cells (Lane 3) and JK cells (Lane 4), using Androgen Receptor (Phospho-Tyr363) Antibody P40462. The lane on the left is treated with antigen-specific peptide.

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

Rabbit Polyclonal Antibody to Androgen Receptor (Phospho-Tyr363)

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