Rabbit Polyclonal Antibody to APC

包装: 1G|100G|500G|1KG|100KG

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别名:APC; APC protein; Adenomatous polyposis coli protein; DP2.5; mAPC
应用:IHC
反应种属:Human
规格：50μl/100μl

Description
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.Matthew Bjerknes, Am. J. Pathol., Jun 1999; 154: 1831. T Maltzman, Carcinogenesis, Dec 1997; 18: 2435 – 2439. Jean Schneikert, Hum. Mol. Genet., Jan 2007; 16: 199 – 209. Dhaval M. Patel, J. Immunol., Nov 1999; 163: 5201

Description

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.Matthew Bjerknes, Am. J. Pathol., Jun 1999; 154: 1831. T Maltzman, Carcinogenesis, Dec 1997; 18: 2435 – 2439. Jean Schneikert, Hum. Mol. Genet., Jan 2007; 16: 199 – 209. Dhaval M. Patel, J. Immunol., Nov 1999; 163: 5201

Specification
Aliases	APC; APC protein; Adenomatous polyposis coli protein; DP2.5; mAPC
Entrez GeneID	324;
Swissprot	P25054
WB Predicted band size	310kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from Internal of human APC.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.