Rabbit Polyclonal Antibody to APCS

包装: 1G|100G|500G|1KG|100KG

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别名:Serum amyloid P-component, SAP, 95S alpha-1-glycoprotein, Serum amyloid P-component(1-203), APCS, PTX2
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

Description

The protein encoded by this gene is a glycoprotein,
belonging to the pentraxin family of proteins, which has a
characteristic pentameric organization. These family members have
considerable sequence homology which is thought to be the result of
gene duplication. The binding of the encoded protein to proteins in
the pathological amyloid cross-beta fold suggests its possible role
as a chaperone. This protein is also thought to control the
degradation of chromatin. It has been demonstrated that this
protein binds to apoptotic cells at an early stage, which raises
the possibility that it is involved in dealing with apoptotic cells
in vivo.

Specification
Aliases	Serum amyloid P-component, SAP, 95S alpha-1-glycoprotein, Serum amyloid P-component(1-203), APCS, PTX2
Entrez GeneID	325
Swissprot	P02743
WB Predicted band size	25.4kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This APCS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-178 amino acids from the C-terminal region of human APCS.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	APCS Antibody (C-term) (Cat. #P30828) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the APCS antibody detected the APCS protein (arrow).
	APCS antibody (C-term) (Cat. #P30828) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the APCS antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.