中文 
别名:p115-RhoGEF; p115RhoGEF; 115 kDa guanine nucleotide exchange factor; Sub1.5;应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.Farmer A., Submitted (MAY-2003).Wedegaertner P.B., J. Biol. Chem. 275:14992-14999(2000).Han D.K., Sci. Signal. 2:RA46-RA46(2009). |
| Specification | |
|---|---|
| Aliases | p115-RhoGEF; p115RhoGEF; 115 kDa guanine nucleotide exchange factor; Sub1.5; |
| Entrez GeneID | 9138; |
| Swissprot | Q92888 |
| WB Predicted band size | 105kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ARHGEF1. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
 |
Western blot analysis of extracts from COLO205, HepG2, HuvEc and Jurkat cells, using ARHGEF1 antibody P42568. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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