Rabbit Polyclonal Antibody to ARHGEF3

包装: 1G|100G|500G|1KG|100KG

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别名:Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN, ARHGEF3
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Description

Rho-like GTPases are involved in a variety of cellular
processes, and they are activated by binding GTP and inactivated by
conversion of GTP to GDP by their intrinsic GTPase activity.
Guanine nucleotide exchange factors (GEFs) accelerate the GTPase
activity of Rho GTPases by catalyzing their release of bound GDP.
This gene encodes a guanine nucleotide exchange factor, which
specifically activates two members of the Rho GTPase family: RHOA
and RHOB, both of which have a role in bone cell biology. It has
been identified that genetic variation in this gene plays a role in
the determination of bone mineral density (BMD), indicating the
implication of this gene in postmenopausal osteoporosis.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.

Specification
Aliases	Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN, ARHGEF3
Entrez GeneID	50650
Swissprot	Q9NR81
WB Predicted band size	59.8kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This ARHGEF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human ARHGEF3.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	ARHGEF3 Antibody (Center) (Cat. #P30719) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ARHGEF3 antibody detected the ARHGEF3 protein (arrow).
	ARHGEF3 Antibody (Center) (Cat. #P30719) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ARHGEF3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.