Rabbit Polyclonal Antibody to ATF3

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别名:Cyclic AMP-dependent transcription factor ATF-3; Activating transcription factor 3; ATF3;
应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
This protein binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AC][AG]-3′), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.Chen B.P.C., J. Biol. Chem. 269:15819-15826(1994).Hai T., Genes Dev. 3:2083-2090(1989).Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).

Description

This protein binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AC][AG]-3′), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.Chen B.P.C., J. Biol. Chem. 269:15819-15826(1994).Hai T., Genes Dev. 3:2083-2090(1989).Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).

Specification
Aliases	Cyclic AMP-dependent transcription factor ATF-3; Activating transcription factor 3; ATF3;
Entrez GeneID	467;
Swissprot	P18847
WB Predicted band size	21kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from internal of human ATF3.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.