Rabbit Polyclonal Antibody to AZI1

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别名:5-azacytidine-induced 1; centrosomal protein of 131 kDa; Cep131; pre-acrosome localization 1;
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Component of centriolar satellites, which build a complex and dynamic network required to regulate cilia/flagellum formation. During normal and stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a p38 MAPK-dependent manner. In contrast, in proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. Acts also as a negative regulator for the trafficking from the centriolar satellite BBSome protein complex to the cilia. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole duplication in non-ciliogenic cells.Kikuno R., DNA Res. 6:197-205(1999).Andersen J.S., Nature 426:570-574(2003).Olsen J.V., Cell 127:635-648(2006).

Description

Component of centriolar satellites, which build a complex and dynamic network required to regulate cilia/flagellum formation. During normal and stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a p38 MAPK-dependent manner. In contrast, in proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. Acts also as a negative regulator for the trafficking from the centriolar satellite BBSome protein complex to the cilia. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole duplication in non-ciliogenic cells.Kikuno R., DNA Res. 6:197-205(1999).Andersen J.S., Nature 426:570-574(2003).Olsen J.V., Cell 127:635-648(2006).

Specification
Aliases	5-azacytidine-induced 1; centrosomal protein of 131 kDa; Cep131; pre-acrosome localization 1;
Entrez GeneID	22994;
Swissprot	Q9UPN4
WB Predicted band size	130kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human AZI1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from HUVEC cells, using AZI1 antibody P42234.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using AZI1 antibody P42234.