Rabbit Polyclonal Antibody to BARD1

包装: 1G|100G|500G|1KG|100KG

现货支持定制

QQ咨询
| 微信咨询

400-880-2824

满200元免运费
正品保障提供发票
现货闪电当时发货

别名:BRCA1-associated RING domain protein 1; BARD-1; BARD1;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of ‘Lys-6′-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3’ cleavage.Wu L.C., Nat. Genet. 14:430-440(1996).Thai T.H., Hum. Mol. Genet. 7:195-202(1998).Hillier L.W., Nature 434:724-731(2005).

Description

Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of ‘Lys-6′-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3’ cleavage.Wu L.C., Nat. Genet. 14:430-440(1996).Thai T.H., Hum. Mol. Genet. 7:195-202(1998).Hillier L.W., Nature 434:724-731(2005).

Specification
Aliases	BRCA1-associated RING domain protein 1; BARD-1; BARD1;
Entrez GeneID	580;
Swissprot	Q99728
WB Predicted band size	79kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from N-terminal of human BARD1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.