Rabbit Polyclonal Antibody to Bax (Ab-167)

包装: 1G|100G|500G|1KG|100KG

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别名:Apoptosis regulator BAX; membrane isoform alpha; BAXA; Bcl2-associated X protein;
应用:WB,ICC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.Oltvai Z.N., Cell 74:609-619(1993).Cuddeback S.M., J. Biol. Chem. 276:20559-20565(2001).Guo B., Nature 423:456-461(2003)

Description

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.Oltvai Z.N., Cell 74:609-619(1993).Cuddeback S.M., J. Biol. Chem. 276:20559-20565(2001).Guo B., Nature 423:456-461(2003)

Specification
Aliases	Apoptosis regulator BAX; membrane isoform alpha; BAXA; Bcl2-associated X protein;
Entrez GeneID	581;
Swissprot	Q07812
WB Predicted band size	21kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized non-phosphopeptide derived from human Bax around the phosphorylation site of threonine 167 (F-G-T(p)-P-T).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
ICC	1/100-1/500

	Western blot analysis of extracts from HepG2 cells, using Bax (Ab-167) antibody P41656.
	Immunofluorescence analysis of LOVO cells, using Bax (Ab-167) antibody P41656.