Rabbit Polyclonal Antibody to Bax (Phospho-Thr167)

包装: 1G|100G|500G|1KG|100KG

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别名:BAXA; Apoptosis regulator BAX; membrane isoform alpha; Bcl2-associated X protein;
应用:ICC
反应种属:Human
规格：50μl/100μl

Description
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.Francesca Andriani. J Natl Cancer Inst, Sep 2001; 93: 1314 – 1324. H Martinez-Valdez. J. Exp. Med., Mar 1996; 183: 971. Joslyn K. Brunelle. J. Biol. Chem., Feb 2004; 279: 4305 – 4312

Description

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.Francesca Andriani. J Natl Cancer Inst, Sep 2001; 93: 1314 – 1324. H Martinez-Valdez. J. Exp. Med., Mar 1996; 183: 971. Joslyn K. Brunelle. J. Biol. Chem., Feb 2004; 279: 4305 – 4312

Specification
Aliases	BAXA; Apoptosis regulator BAX; membrane isoform alpha; Bcl2-associated X protein;
Entrez GeneID	581;
Swissprot	Q07812
WB Predicted band size	21kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of threonine167 (P-G-T(p)-P-T) derived from Human Bax.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.