Rabbit Polyclonal Antibody to BAZ2A

包装: 1G|100G|500G|1KG|100KG

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别名:BA2A; BAZ2A; bromodomain adjacent to zinc finger domain 2A; hWALp3; KIAA0314
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on ‘Lys-16’ (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing By similarity.Jones M.H., Genomics 63:40-45(2000).Bechtel S., BMC Genomics 8:399-399(2007).Scherer S.E., Nature 440:346-351(2006).

Description

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on ‘Lys-16’ (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing By similarity.Jones M.H., Genomics 63:40-45(2000).Bechtel S., BMC Genomics 8:399-399(2007).Scherer S.E., Nature 440:346-351(2006).

Specification
Aliases	BA2A; BAZ2A; bromodomain adjacent to zinc finger domain 2A; hWALp3; KIAA0314
Entrez GeneID	11176;;
Swissprot	Q9UIF9
WB Predicted band size	210kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human BAZ2A.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.