Rabbit Polyclonal Antibody to BCAS3

包装: 1G|100G|500G|1KG|100KG

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别名:MAAB; GAOB1
应用:IHC
反应种属:Human, Mouse
规格：50μl/100μl

Description
BCAS3 (breast carcinoma amplified sequence 3), also designated MAAB or GAOB1, is a 913 amino acid protein that is believed to be involved in breast cancer progression. The gene is regulated by ERå (estrogen receptor alpha) and expressed in multiple tissues, including malignant human brain lesions. It is overexpressed and amplified in breast cancer cell lines. BCAS3 contains three WD40 repeat regions, a bromodomain, a rare zinc-finger motif, four probable DNA-binding domains, and two kinase-inducible phosphorylation domains. Five variants are produced due to alternative splicing. BCAS3 interacts with histone H3 and PCAF, which is indicative of histone acetyltransferase activity. BCAS3 also exhibits ERå transactiviation activity by acting as a coactivator with PELP1 or MTA1. The amplification and translocation between the BCAS3 gene and the BCAS4 gene results in a fusion transcript is overexpressed in MCF-7 cells.

Description

BCAS3 (breast carcinoma amplified sequence 3), also designated MAAB or GAOB1, is a 913 amino acid protein that is believed to be involved in breast cancer progression. The gene is regulated by ERå (estrogen receptor alpha) and expressed in multiple tissues, including malignant human brain lesions. It is overexpressed and amplified in breast cancer cell lines. BCAS3 contains three WD40 repeat regions, a bromodomain, a rare zinc-finger motif, four probable DNA-binding domains, and two kinase-inducible phosphorylation domains. Five variants are produced due to alternative splicing. BCAS3 interacts with histone H3 and PCAF, which is indicative of histone acetyltransferase activity. BCAS3 also exhibits ERå transactiviation activity by acting as a coactivator with PELP1 or MTA1. The amplification and translocation between the BCAS3 gene and the BCAS4 gene results in a fusion transcript is overexpressed in MCF-7 cells.

Specification
Aliases	MAAB; GAOB1
Swissprot	Q9H6U6
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Synthetic peptide of human BCAS3
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/50-1/200
ELISA	1/2000-1/5000

	The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11237(BCAS3 Antibody) at dilution 1/40. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11237(BCAS3 Antibody) at dilution 1/40. (Original magnification: ×200)