Rabbit Polyclonal Antibody to BCL2L12

包装: 1G|100G|500G|1KG|100KG

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别名:Bcl-2-like protein 12; Bcl2-L-12; Bcl-2-related proline-rich protein;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.Scorilas A., Genomics 72:217-221(2001) [PubMed: 11401436].Hillman R.T., Genome Biol. 5:R8.1-R8.16(2004) [PubMed: 14759258].Olsen J.V., Cell 127:635-648(2006) [PubMed: 17081983].

Description

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.Scorilas A., Genomics 72:217-221(2001) [PubMed: 11401436].Hillman R.T., Genome Biol. 5:R8.1-R8.16(2004) [PubMed: 14759258].Olsen J.V., Cell 127:635-648(2006) [PubMed: 17081983].

Specification
Aliases	Bcl-2-like protein 12; Bcl2-L-12; Bcl-2-related proline-rich protein;
Entrez GeneID	83596;
Swissprot	Q9HB09
WB Predicted band size	34kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human BCL2L12.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.