Rabbit Polyclonal Antibody to BCOR

包装: 1G|100G|500G|1KG|100KG

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别名:BCL-6 corepressor; BCoR; BCOR; KIAA1575;
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ‘Lys-4’ (H3K4me3) and ‘Lys-36’ (H3K36me2).Huynh K.D., Genes Dev. 14:1810-1823(2000).Ng D., Nat. Genet. 36:411-416(2004).Nagase T., DNA Res. 7:273-281(2000).

Description

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ‘Lys-4’ (H3K4me3) and ‘Lys-36’ (H3K36me2).Huynh K.D., Genes Dev. 14:1810-1823(2000).Ng D., Nat. Genet. 36:411-416(2004).Nagase T., DNA Res. 7:273-281(2000).

Specification
Aliases	BCL-6 corepressor; BCoR; BCOR; KIAA1575;
Entrez GeneID	54880;
Swissprot	Q6W2J9
WB Predicted band size	192kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human BCOR.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from COLO cells, using BCOR antibody P42166.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using BCOR antibody P42166.