Rabbit Polyclonal Antibody to BEAN (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Protein BEAN1, Brain-expressed protein associating with Nedd4 homolog, BEAN, BEAN1
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Description

The protein encoded by this gene is one of several
proteins that interact with NEDD4, a member of a family of
ubiquitin-protein ligases. These proteins have PY motifs in common
that bind to the WW domains of NEDD4. NEDD4 is developmentally
regulated, and is highly expressed in embryonic tissues. Mutations
in this gene (i.e., intronic insertions of >100 copies of
pentanucleotide repeats including a (TGGAA)n sequence) are
associated with spinocerebellar ataxia type 31. Alternatively
spliced transcript variants encoding different isoforms have been
found for this gene.

Specification
Aliases	Protein BEAN1, Brain-expressed protein associating with Nedd4 homolog, BEAN, BEAN1
Entrez GeneID	146227
Swissprot	Q3B7T3
WB Predicted band size	28.6kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This BEAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-73 amino acids from the N-terminal region of human BEAN.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	BEAN Antibody (N-term) (Cat. #P31278) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the BEAN antibody detected the BEAN protein (arrow).
	BEAN Antibody (N-term) (Cat. #P31278)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BEAN Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.