Rabbit Polyclonal Antibody to BL-CAM (Ab-807)

包装: 1G|100G|500G|1KG|100KG

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别名:B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Leu-14; Siglec-2
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.Wilson G.L., J. Exp. Med. 173:137-146(1991).Wilson G.L., J. Immunol. 150:5013-5024(1993).Stamenkovic I., Nature 345:74-77(1990).

Description

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.Wilson G.L., J. Exp. Med. 173:137-146(1991).Wilson G.L., J. Immunol. 150:5013-5024(1993).Stamenkovic I., Nature 345:74-77(1990).

Specification
Aliases	B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Leu-14; Siglec-2
Entrez GeneID	933;
Swissprot	P20273
WB Predicted band size	90kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human BL-CAM around the phosphorylation site of tyrosine 807 (G-D-Y(p)-E-N).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.