Rabbit Polyclonal Antibody to BMX

包装: 1G|100G|500G|1KG|100KG

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别名:BMX; BMX NON-receptor tyrosine kinase; Bone marrow kinase BMX; Cytoplasmic BMX; EC 2.7.10.2
应用:WB,IHC,ICC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.Tamagnone L., Oncogene 9:3683-3688(1994).Qiu Y., Proc. Natl. Acad. Sci. U.S.A. 95:3644-3649(1998).Fuortes M., Thesis (1994), Cornell University, United States.

Description

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.Tamagnone L., Oncogene 9:3683-3688(1994).Qiu Y., Proc. Natl. Acad. Sci. U.S.A. 95:3644-3649(1998).Fuortes M., Thesis (1994), Cornell University, United States.

Specification
Aliases	BMX; BMX NON-receptor tyrosine kinase; Bone marrow kinase BMX; Cytoplasmic BMX; EC 2.7.10.2
Entrez GeneID	660;
Swissprot	P51813
WB Predicted band size	75kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from N-terminal of human BMX.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100
ICC	1/100-1/500

	Western blot analysis of extracts from COS-7 cells, using BMX antibody P41959.
	Immunofluorescence analysis of A549 cells, using BMX antibody P41959.
	Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue using BMX antibody P41959.