中文 
别名:BRCC2; BRCA2; subunit 2; BRCA1/BRCA2-containing complex;应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl
| Description |
|---|
| Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. Wooster R., Nature 378:789-792(1995)Tavtigian S.V., Nat. Genet. 12:333-337(1996)Dunham A., Nature 428:522-528(2004) |
| Specification | |
|---|---|
| Aliases | BRCC2; BRCA2; subunit 2; BRCA1/BRCA2-containing complex; |
| Entrez GeneID | 675; |
| Swissprot | P51587 |
| WB Predicted band size | >350kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of Serine 3291 (F-V-S(p)-P-A) derived from Human BRCA2. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
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Western blot analysis of extracts from 293 cells using BRCA2 (Phospho-Ser3291) Antibody P40539.The lane on the right is treated with the antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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