Rabbit Polyclonal Antibody to BSCL2 (N-term)

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别名:Seipin, Bernardinelli-Seip congenital lipodystrophy type 2 protein, BSCL2
应用:WB,IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
This gene encodes protein seipin, which is located in the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Description

This gene encodes protein seipin, which is located in the
endoplasmic reticulum and may be important for lipid droplet
morphology. Mutations in this gene have been associated with
congenital generalized lipodystrophy type 2 or Berardinelli-Seip
syndrome, a rare autosomal recessive disease characterized by a
near absence of adipose tissue and severe insulin resistance.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.

Specification
Aliases	Seipin, Bernardinelli-Seip congenital lipodystrophy type 2 protein, BSCL2
Entrez GeneID	26580
Swissprot	Q96G97
WB Predicted band size	44.4kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	This BSCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-107 amino acids from the N-terminal region of human BSCL2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000-1/2000
IHC	1/100-1/500

	All lanes : Anti-BSCL2 Antibody (N-term) at 1:2000 dilution Lane 1: Human testis lysate Lane 2: Mouse testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 44 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
	All lanes : Anti-BSCL2 Antibody (N-term) at 1:2000 dilution Lane 1: Human testis lysate Lane 2: Mouse testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 44 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
	BSCL2 Antibody (N-term) (Cat. #P34384) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the BSCL2 antibody detected the BSCL2 protein (arrow).
	BSCL2 Antibody (N-term) (Cat. #P34384) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BSCL2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.