中文 
别名:AGMX1; ATK; kinase Btk; BPK;应用:WB
反应种属:Human,Mouse
规格：50μl/100μl
| Description |
|---|
| Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. Sulekha Verma, J. Biol. Chem., Feb 2001; 276: 4671 – 4676Yan M. Li, Cancer Res., Nov 2003; 63: 7630 – 7633Malti Nikrad, Mol. Cancer Ther., Mar 2005; 4: 443 – 449Feng Dong, Infect. Immun., Mar 2005; 73: 1861 – 1864Hiroo Ueno, Mol. Biol. Cell, Feb 2 |
| Specification | |
|---|---|
| Aliases | AGMX1; ATK; kinase Btk; BPK; |
| Entrez GeneID | 695; |
| Swissprot | Q06187 |
| WB Predicted band size | 80kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 223 (A-L-Y(p)-D-Y) derived from Human BTK. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
 |
Western blot analysis of extracts from Hela cells treated with serum using BTK (phospho-Tyr223) Antibody P40369.The lane on the right is treated with the antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
暂无评论
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
发表回复