Rabbit Polyclonal Antibody to CABLES2

包装: 1G|100G|500G|1KG|100KG

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别名:ik3-2; C20orf150; dJ908M14.2
应用:IHC
反应种属:Human, Mouse
规格：50μl/100μl

Description
Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78% sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene.

Description

Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78% sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene.

Specification
Aliases	ik3-2; C20orf150; dJ908M14.2
Swissprot	Q9BTV7
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Synthetic peptide of human CABLES2
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/25-1/100
ELISA	1/1000-1/2000

	The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11612(CABLES2 Antibody) at dilution 1/25. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11612(CABLES2 Antibody) at dilution 1/25. (Original magnification: ×200)