中文 
别名:PYR1; CAD protein; EC 2.1.3.2; EC 3.5.2.3;应用:IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.Iwahana H., Biochem. Biophys. Res. Commun. 219:249-255(1996)Davidson J.N., DNA Cell Biol. 9:667-676(1990)Olsen J.V., Cell 127:635-648(2006) |
| Specification | |
|---|---|
| Aliases | PYR1; CAD protein; EC 2.1.3.2; EC 3.5.2.3; |
| Entrez GeneID | 790; |
| Swissprot | P27708 |
| WB Predicted band size | 242kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of threonine 456 (P-I-T(p)-P-H) derived from Human CAD. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| IHC | 1/50-1/100 |
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Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using CAD (Phospho-Thr456) antibody P40489 (left)or the same antibody preincubated with blocking peptide (right). |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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