Rabbit Polyclonal Antibody to CaMKII alpha/delta

包装: 1G|100G|500G|1KG|100KG

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别名:CAMK2A; CAMKA; KIAA0968; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2D; CAMKD; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II
应用:WB,IHC,ICC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
The product of CAMK2A (calcium/calmodulin dependent protein kinase II alpha) belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for CAMK2A.

Description

The product of CAMK2A (calcium/calmodulin dependent protein kinase II alpha) belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for CAMK2A.

Specification
Aliases	CAMK2A; CAMKA; KIAA0968; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2D; CAMKD; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II
Entrez GeneID	815/817
Swissprot	Q9UQM7/Q13557
WB Predicted band size	Calculated MW: 54 kDa; Observed MW: 54 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	The antiserum was produced against synthesized peptide derived from human CaMK2 alpha/delta. AA range:256-305
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200
ELISA	1/10000

	Western blot analysis of CaMKII alpha/delta in NIH3T3/K562 lysates using CaMKII alpha/delta antibody.
	Western blot analysis of CaMKII alpha/delta in NIH/3T3 and K562 lysates using CaMKII alpha/delta antibody.The lane on the right is blocked with the synthesized peptide.
	Immunofluorescence analysis of CaMKII alpha/delta in MCF-7 using CaMK2 alpha/delta antibody. The picture on the right is blocked using the synthesized peptide.
	Immunohistochemistry analysis of paraffin-embedded Human brain tissue using CaMK2 alpha/delta antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.