Rabbit Polyclonal Antibody to CAPNS1

包装: 1G|100G|500G|1KG|100KG

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别名:calpain, small subunit 1, 30K, CANP, CDPS, CSS1, CANPS, CAPN4, CALPAIN4
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.

Description

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.

Specification
Aliases	calpain, small subunit 1, 30K, CANP, CDPS, CSS1, CANPS, CAPN4, CALPAIN4
Entrez GeneID	826;
Swissprot	P04632
WB Predicted band size	28kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Fusion protein corresponding to a region derived from 91-268 amino acids of human calpain, small subunit 1
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
WB	1/200-1/1000
IHC	1/25-1/100
ELISA	1:1000-1:2000

	Gel: 12%SDS-PAGELane1: Mouse spleen tissue lysateLane2: K562 cell lysateLane3: NIH/3T3 cell lysateLysates: 60 ug per lanePrimary antibody: 1/200 dilutionSecondary antibody: Goat anti Rabbit IgG – H&L (HRP) at 1/10000 dilutionExposure time: 15 seconds
	The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using 31040 (CAPNS1 Antibody) at dilution 1/15, on the right is treated with the fusion protein.