Rabbit Polyclonal Antibody to CATB

包装: 1G|100G|500G|1KG|100KG

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别名:Cathepsin B, APP secretase, APPS, Cathepsin B1, Cathepsin B light chain, Cathepsin B heavy chain, CTSB, CPSB
应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl

Description
The protein CATB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors.

Description

The protein CATB is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors.

Specification
Aliases	Cathepsin B, APP secretase, APPS, Cathepsin B1, Cathepsin B light chain, Cathepsin B heavy chain, CTSB, CPSB
Entrez GeneID	1508
Swissprot	P07858
WB Predicted band size	37.8kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CATB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the Central region of human CATB.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
FCM	1/10-1/50

	Western blot analysis of CATB Antibody (Center) (Cat.# P30372) in Y79 cell line lysates (35ug/lane). CATB (arrow) was detected using the purified Pab.
	Flow cytometric analysis of HepG2 cells using CATB Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	Formalin-fixed and paraffin-embedded human hepatocarcinoma with CATB Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.