Rabbit Polyclonal Antibody to Catenin-δ1 (Ab-228)

包装: 1G|100G|500G|1KG|100KG

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别名:CAS; CATNS; CTD1; CTND1; Cadherin-associated Src substrate
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway By similarity. Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.Keirsebilck A., Genomics 50:129-146(1998).Nagase T., DNA Res. 4:141-150(1997).W.S., Sherwood J.K., Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.

Description

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway By similarity. Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.Keirsebilck A., Genomics 50:129-146(1998).Nagase T., DNA Res. 4:141-150(1997).W.S., Sherwood J.K., Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.

Specification
Aliases	CAS; CATNS; CTD1; CTND1; Cadherin-associated Src substrate
Entrez GeneID	1500;
Swissprot	O60716
WB Predicted band size	108kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human Catenin-δ1 around the phosphorylation site of tyrosine 228 (D-N-Y(p)-G-S).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from HuvEc cells, using Catenin-δ1 (Ab-228) antibody P41662.
	Western blot analysis of extracts from 293 cells (Lane 2), using Catenin-δ1 (Ab-228) antiobdy P41662. The lane on the left is treated with synthesized peptide.
	Immunohistochemistry analysis of paraffin-embedded human brain tissue using Catenin-δ1 (Ab-228) antibody P41662.