中文 
别名:C-CBL; CBL2; Proto-oncogene c-Cbl; RNF55;应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl
| Description |
|---|
| Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.Fernandes MS, et al. (2010) J Biol Chem 285, 32596-605 Teckchandani AM, Panetti TS, Tsygankov AY (2005) Exp Cell Res 307, 247-58 |
| Specification | |
|---|---|
| Aliases | C-CBL; CBL2; Proto-oncogene c-Cbl; RNF55; |
| Entrez GeneID | 867; |
| Swissprot | P22681 |
| WB Predicted band size | 120kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of Tyrosine674 (A-I-Y(p)-S-L) derived from Human CBL. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
 |
Western blot analysis of extracts from HepG2 cells treated with Na2VO3 using Phospho-CBL (Tyr674) antibody P40583.The lane on the right is treated with the antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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