Rabbit Polyclonal Antibody to CCNT1

包装: 1G|100G|500G|1KG|100KG

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别名:Cyclin-T1, CycT1, Cyclin-T, CCNT1
应用:WB
反应种属:Human, Mouse
规格：50μl/100μl

Description
CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.

Description

CCNT1 belongs to the highly
conserved cyclin family, whose members are characterized by a
dramatic periodicity in protein abundance through the cell cycle.
Cyclins function as regulators of CDK kinases. Different cyclins
exhibit distinct expression and degradation patterns which
contribute to the temporal coordination of each mitotic event. This
cyclin tightly associates with CDK9 kinase, and was found to be a
major subunit of the transcription elongation factor p-TEFb. The
kinase complex containing this cyclin and the elongation factor can
interact with, and act as a cofactor of human immunodeficiency
virus type 1 (HIV-1) Tat protein, and was shown to be both
necessary and sufficient for full activation of viral
transcription. This cyclin and its kinase partner were also found
to be involved in the phosphorylation and regulation of the
carboxy-terminal domain (CTD) of the largest RNA polymerase II
subunit.

Specification
Aliases	Cyclin-T1, CycT1, Cyclin-T, CCNT1
Entrez GeneID	904
Swissprot	O60563
WB Predicted band size	80.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This CCNT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-281 amino acids from the Central region of human CCNT1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000

All lanes : Anti-CCNT1 Antibody (Center) at 1:1000 dilution
Lane 1: Hela whole cell lysate
Lane 2: MCF-7 whole cell lysate
Lane 3: HL-60 whole cell lysate
Lane 4: Jurkat whole cell lysate
Lane 5: K562 whole cell lysate
Lane 6: SH-SY5Y whole cell lysate

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 81 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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