Rabbit Polyclonal Antibody to CCR10 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2, CCR10, GPR2
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).

Description

Chemokines are a group of small (approximately 8 to 14
kD), mostly basic, structurally related molecules that regulate
cell trafficking of various types of leukocytes through
interactions with a subset of 7-transmembrane, G protein-coupled
receptors. Chemokines also play fundamental roles in the
development, homeostasis, and function of the immune system, and
they have effects on cells of the central nervous system as well as
on endothelial cells involved in angiogenesis or angiostasis.
Chemokines are divided into 2 major subfamilies, CXC and CC, based
on the arrangement of the first 2 of the 4 conserved cysteine
residues; the 2 cysteines are separated by a single amino acid in
CXC chemokines and are adjacent in CC chemokines. CCR10 is the
receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions
are involved in T cell-mediated skin inflammation (Homey et al.,
2002 [PubMed 11821900]).

Specification
Aliases	C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2, CCR10, GPR2
Entrez GeneID	2826
Swissprot	P46092
WB Predicted band size	38.4kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CCR10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCR10.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.