Rabbit Polyclonal Antibody to CCT4 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:T-complex protein 1 subunit delta, TCP-1-delta, CCT-delta, Stimulator of TAR RNA-binding, CCT4, CCTD, SRB
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).

Description

The chaperonin containing TCP1 (MIM 186980) complex (CCT),
also called the TCP1 ring complex, consists of 2 back-to-back
rings, each containing 8 unique but homologous subunits, such as
CCT4. CCT assists the folding of newly translated polypeptide
substrates through multiple rounds of ATP-driven release and
rebinding of partially folded intermediate forms. Substrates of CCT
include the cytoskeletal proteins actin (see MIM 102560) and
tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330)
(Won et al., 1998 [PubMed 9819444]).

Specification
Aliases	T-complex protein 1 subunit delta, TCP-1-delta, CCT-delta, Stimulator of TAR RNA-binding, CCT4, CCTD, SRB
Entrez GeneID	10575
Swissprot	P50991
WB Predicted band size	57.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CCT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human CCT4.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	CCT4 Antibody (N-term) (Cat. #P31554) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CCT4 antibody detected the CCT4 protein (arrow).
	CCT4 Antibody (N-term) (P31554)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CCT4 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.