别名:B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1应用:WB,IHC
反应种属:Human, Mouse
规格:50μl/100μl
Description |
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This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. |
Specification | |
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Aliases | B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1 |
Swissprot | Q9NZQ7 |
WB Predicted band size | 33 kDa |
Host/Isotype | Rabbit IgG |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Synthetic peptide of human CD274 |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Application | |
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WB | 1/500-1/2000 |
IHC | 1/50-1/100 |
ELISA | 1/5000-1/10000 |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 231, Raji, RAW264.7, Hela, NIH/3T3 cell lysates, Primary antibody: P06083(CD274 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute | |
The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P06083(CD274 Antibody) at dilution 1/50. (Original magnification: ×200) |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的,不可用于人类或动物的临床诊断或治疗,非药用,非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的,不可用于人类或动物的临床诊断或治疗,非药用,非食用。
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