Rabbit Polyclonal Antibody to CD2BP2 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, CD2 tail-binding protein 2, U5 snRNP 52K protein, U5-52K, CD2BP2, KIAA1178
应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.

Description

This gene encodes a bi-functional protein. In the
cytoplasm, the encoded protein binds the cytoplasmic tail of human
surface antigen CD2 via its C-terminal GYF domain, and regulate
CD2-triggered T lymphocyte activation. In the nucleus, this protein
is a component of the U5 small nuclear ribonucleoprotein complex
and is involved in RNA splicing. A pseudogene has been identified
on chromosome 7. Alternative splicing results in multiple
transcript variants but their biological validity has not been
determined.

Specification
Aliases	CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, CD2 tail-binding protein 2, U5 snRNP 52K protein, U5-52K, CD2BP2, KIAA1178
Entrez GeneID	10421
Swissprot	O95400
WB Predicted band size	37.6kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CD2BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human CD2BP2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
FCM	1/10-1/50

	CD2BP2 Antibody (N-term) (Cat. #P30879) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CD2BP2 antibody detected the CD2BP2 protein (arrow).
	CD2BP2 Antibody (N-term) (Cat. #P30879) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	CD2BP2 antibody(N-term) (Cat. #P30879) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CD2BP2 antibody(N-term) for immunohistochemistry. Clinical relevance has not been evaluated.