Rabbit Polyclonal Antibody to CD3E

包装: 1G|100G|500G|1KG|100KG

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别名:T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E
应用:WB
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.

Description

The protein encoded by this gene is the CD3-epsilon
polypeptide, which together with CD3-gamma, -delta and -zeta, and
the T-cell receptor alpha/beta and gamma/delta heterodimers, forms
the T-cell receptor-CD3 complex. This complex plays an important
role in coupling antigen recognition to several intracellular
signal-transduction pathways. The genes encoding the epsilon, gamma
and delta polypeptides are located in the same cluster on
chromosome 11. The epsilon polypeptide plays an essential role in
T-cell development. Defects in this gene cause immunodeficiency.
This gene has also been linked to a susceptibility to type I
diabetes in women.

Specification
Aliases	T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E
Entrez GeneID	916
Swissprot	P07766
WB Predicted band size	23.1kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CD3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-182 amino acids from the C-terminal region of human CD3E.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000

	CD3E Antibody (C-term) (Cat. #P31303) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CD3E antibody detected the CD3E protein (arrow).
	Western blot analysis of CD3E (arrow) using rabbit polyclonal CD3E Antibody (C-term) (Cat. #P31303). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CD3E gene.