Rabbit Polyclonal Antibody to CD40

包装: 1G|100G|500G|1KG|100KG

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别名:Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD40, CD40, TNFRSF5
应用:WB
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Description

The protein encoded by this gene is a member of the
TNF-receptor superfamily. This receptor has been found to be
essential in mediating a broad variety of immune and inflammatory
responses including T cell-dependent immunoglobulin class
switching, memory B cell development, and germinal center
formation. AT-hook transcription factor AKNA is reported to
coordinately regulate the expression of this receptor and its
ligand, which may be important for homotypic cell interactions.
Adaptor protein TNFR2 interacts with this receptor and serves as a
mediator of the signal transduction. The interaction of this
receptor and its ligand is found to be necessary for
amyloid-beta-induced microglial activation, and thus is thought to
be an early event in Alzheimer disease pathogenesis. Two
alternatively spliced transcript variants of this gene encoding
distinct isoforms have been reported.

Specification
Aliases	Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD40, CD40, TNFRSF5
Entrez GeneID	958
Swissprot	P25942
WB Predicted band size	30.6kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CD40 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the C-terminal region of human CD40.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000

	Western blot analysis of lysate from human spleen tissue lysate, using CD40 Antibody (C-term)(Cat. #P32792). P32792 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
	CD40 Antibody (C-term) (Cat. #P32792) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CD40 antibody detected the CD40 protein (arrow).