中文 
别名:CDC25M2; MPIP2; Dual specificity phosphatase Cdc25B; CDC25HU2;应用:WB
反应种属:Human,Mouse
规格：50μl/100μl
| Description |
|---|
| Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. Reboutier D, et al. (2012) J Cell Biol 197, 19-26 Lobjois V, et al. (2011) Biochem Biophys Res Commun 410, 87-90 Feng C, et al. (2007) Biol Reprod 77, 560-8 |
| Specification | |
|---|---|
| Aliases | CDC25M2; MPIP2; Dual specificity phosphatase Cdc25B; CDC25HU2; |
| Entrez GeneID | 994; |
| Swissprot | P30305 |
| WB Predicted band size | 64kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of serine 353(R-R-S(p)-V-T) derived from Human CDC25B . |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
 |
Western blot analysis of extracts from COS7 cells treated with Etoposide using Phospho-CDC25B (Ser353) antibody P40586.The lane on the right is treated with the antigen-specific peptide. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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