Rabbit Polyclonal Antibody to CDC42EP2

包装: 1G|100G|500G|1KG|100KG

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别名:Cdc42 effector protein 2, Binder of Rho GTPases 1, CDC42EP2, BORG1, CEP2
应用:WB
反应种属:Human, Mouse
规格：50μl/100μl

Description
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.

Description

CDC42, a small Rho GTPase, regulates the formation of
F-actin-containing structures through its interaction with the
downstream effector proteins. The protein encoded by this gene is a
member of the Borg family of CDC42 effector proteins. Borg family
proteins contain a CRIB (Cdc42/Rac interactive-binding) domain.
They bind to, and negatively regulate the function of, CDC42.
Coexpression of this protein with dominant negative mutant CDC42
protein in fibroblast was found to induce pseudopodia formation,
which suggested a role of this protein in actin filament assembly
and cell shape control.

Specification
Aliases	Cdc42 effector protein 2, Binder of Rho GTPases 1, CDC42EP2, BORG1, CEP2
Entrez GeneID	10435
Swissprot	O14613
WB Predicted band size	22.5kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This CDC42EP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-160 amino acids from the C-terminal region of human CDC42EP2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000

	CDC42EP2 Antibody (C-term) (Cat. #P31749) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CDC42EP2 antibody detected the CDC42EP2 protein (arrow).
	CDC42EP2 Antibody (C-term) (Cat. #P31749) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the CDC42EP2 antibody detected the CDC42EP2 protein (arrow).