Rabbit Polyclonal Antibody to CDH7 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Cadherin-7, CDH7, CDH7L1
应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl

Description
CDH7 is a type II classical cadherin from the cadherin superfamily. This protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures.

Description

CDH7 is a type II classical cadherin from the cadherin superfamily. This protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures.

Specification
Aliases	Cadherin-7, CDH7, CDH7L1
Entrez GeneID	1005
Swissprot	Q9ULB5
WB Predicted band size	87.1kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CDH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-84 amino acids from the N-terminal region of human CDH7.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
FCM	1/10-1/50

	Western blot analysis of anti-CDH7 Pab (Cat.#P30247) in K562 cell line lysates (35ug/lane). CDH7(arrow) was detected using the purified Pab.
	Flow cytometric analysis of NCI-H292 cells using Cadherin 7 (CDH7) Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with CDH7 antibody (N-term) (Cat.#P30247), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.