Rabbit Polyclonal Antibody to CELA3B (N-term)

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别名:Chymotrypsin-like elastase family member 3B, Elastase IIIB, Elastase-3B, Protease E, CELA3B, ELA3B
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

Description

Elastases form a subfamily of serine proteases that
hydrolyze many proteins in addition to elastin. Humans have six
elastase genes which encode the structurally similar proteins
elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase
3B has little elastolytic activity. Like most of the human
elastases, elastase 3B is secreted from the pancreas as a zymogen
and, like other serine proteases such as trypsin, chymotrypsin and
kallikrein, it has a digestive function in the intestine. Elastase
3B preferentially cleaves proteins after alanine residues. Elastase
3B may also function in the intestinal transport and metabolism of
cholesterol. Both elastase 3A and elastase 3B have been referred to
as protease E and as elastase 1, and excretion of this protein in
fecal material is frequently used as a measure of pancreatic
function in clinical assays.

Specification
Aliases	Chymotrypsin-like elastase family member 3B, Elastase IIIB, Elastase-3B, Protease E, CELA3B, ELA3B
Entrez GeneID	23436
Swissprot	P08861
WB Predicted band size	29.3kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CELA3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human CELA3B.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	CELA3B Antibody (N-term) (Cat. #P31338) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CELA3B antibody detected the CELA3B protein (arrow).
	CELA3B Antibody (N-term) (Cat. #P31338)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CELA3B Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.