别名:BM88应用:IHC
反应种属:Human, Mouse, Rat
规格:50μl/100μl
Description |
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BM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A. |
Specification | |
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Aliases | BM88 |
Swissprot | Q8N111 |
Host/Isotype | Rabbit IgG |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Synthetic peptide of human CEND1 |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Application | |
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IHC | 1/25-1/100 |
ELISA | 1/5000-1/10000 |
The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P06176(CEND1 Antibody) at dilution 1/30. (Original magnification: ×200) | |
The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P06176(CEND1 Antibody) at dilution 1/30. (Original magnification: ×200) |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的,不可用于人类或动物的临床诊断或治疗,非药用,非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的,不可用于人类或动物的临床诊断或治疗,非药用,非食用。
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