Rabbit Polyclonal Antibody to CENPA

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别名:CENA; CENP-A; Centromere autoantigen A; Centromere protein A;
应用:IHC
反应种属:Human
规格：50μl/100μl

Description
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).Sullivan K.F., J. Cell Biol. 127:581-592(1994).Hillier L.W., Nature 434:724-731(2005).Shelby R.D., J. Cell Biol. 136:501-513(1997).

Description

Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).Sullivan K.F., J. Cell Biol. 127:581-592(1994).Hillier L.W., Nature 434:724-731(2005).Shelby R.D., J. Cell Biol. 136:501-513(1997).

Specification
Aliases	CENA; CENP-A; Centromere autoantigen A; Centromere protein A;
Entrez GeneID	1058;
Swissprot	P49450
WB Predicted band size	16kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human CENPA.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.