Rabbit Polyclonal Antibody to CHMP2B (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Charged multivesicular body protein 2b, CHMP25, Chromatin-modifying protein 2b, CHMP2b, Vacuolar protein sorting-associated protein 2-2, Vps2-2, hVps2-2, CHMP2B
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.

Description

This gene encodes a component of the heteromeric ESCRT-III
complex (Endosomal Sorting Complex Required for Transport III) that
functions in the recycling or degradation of cell surface
receptors. ESCRT-III functions in the concentration and
invagination of ubiquitinated endosomal cargos into intralumenal
vesicles. The protein encoded by this gene is found as a monomer in
the cytosol or as an oligomer in ESCRT-III complexes on endosomal
membranes. It is expressed in neurons of all major regions of the
brain. Mutations in this gene result in one form of familial
frontotemporal lobar degeneration.

Specification
Aliases	Charged multivesicular body protein 2b, CHMP25, Chromatin-modifying protein 2b, CHMP2b, Vacuolar protein sorting-associated protein 2-2, Vps2-2, hVps2-2, CHMP2B
Entrez GeneID	25978
Swissprot	Q9UQN3
WB Predicted band size	23.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CHMP2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CHMP2B.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	CHMP2B Antibody (N-term) (Cat. #P31260) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the CHMP2B antibody detected the CHMP2B protein (arrow).
	CHMP2B Antibody (N-term) (Cat. #P31260)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CHMP2B Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.