Rabbit Polyclonal Antibody to CHRM4

包装: 1G|100G|500G|1KG|100KG

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别名:HM4; M4R
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition.

Description

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition.

Specification
Aliases	HM4; M4R
Entrez GeneID	1132;
Swissprot	P08173
WB Predicted band size	53kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide corresponding to a region derived from internal residues of human Cholinergic receptor muscarinic 4
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
WB	1/1000-1/5000
IHC	1/100-1/300

	Gel: 8% SDS-PAGELysate: 40 ugLane: Raji cell lysatePrimary antibody: CHRM4 Antibody at dilution 1/800Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilutionExposure time: 30 seconds
	The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CHRM4 Antibody at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification:x200)