Rabbit Polyclonal Antibody to CIITA

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别名:MHC class II transactivator; CIITA; CIITA; MHC2TA;
应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at ‘Ser-37’ and other histones (in vitro).Steimle V., Cell 75:135-146(1993).Al-Kandari W., J. Mol. Biol. 369:1175-1187(2007).Al-Kandari W., Mol. Immunol. 44:311-321(2007).Croager E.J., Biochim. Biophys. Acta 1353:231-235(1997).

Description

Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at ‘Ser-37’ and other histones (in vitro).Steimle V., Cell 75:135-146(1993).Al-Kandari W., J. Mol. Biol. 369:1175-1187(2007).Al-Kandari W., Mol. Immunol. 44:311-321(2007).Croager E.J., Biochim. Biophys. Acta 1353:231-235(1997).

Specification
Aliases	MHC class II transactivator; CIITA; CIITA; MHC2TA;
Entrez GeneID	4261;
Swissprot	P33076
WB Predicted band size	123kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from internal of human CIITA.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.