Rabbit Polyclonal Antibody to CK-1α (Phospho-Tyr294)

包装: 1G|100G|500G|1KG|100KG

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别名:KC1A; CKI-alpha; CSNK1A1; alpha isoform; Casein kinase I
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ‘Ser-45’. May play a role in segregating chromosomes during mitosis.Tapia C., FEBS Lett. 349:307-312(1994)Fish K.J., J. Biol. Chem. 270:14875-14883(1995)Halleck A., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases

Description

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ‘Ser-45’. May play a role in segregating chromosomes during mitosis.Tapia C., FEBS Lett. 349:307-312(1994)Fish K.J., J. Biol. Chem. 270:14875-14883(1995)Halleck A., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases

Specification
Aliases	KC1A; CKI-alpha; CSNK1A1; alpha isoform; Casein kinase I
Entrez GeneID	1452;
Swissprot	P48729
WB Predicted band size	37kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of tyrosine 294 (Y-D-Y(p)-T-F) derived from Human CK-1α.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from HT-29 cells treated with heat shock using CK-1α (Phospho-Tyr294) Antibody P40432.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human brain tissue using CK-1α (Phospho-Tyr294) antibody P40432 (left)or the same antibody preincubated with blocking peptide (right).