Rabbit Polyclonal Antibody to Claudin 1 (Ab-210)

包装: 1G|100G|500G|1KG|100KG

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别名:CLD1; CLDN1; SEMP1; Senescence-associated epithelial membrane protein; UNQ481/PRO944
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.Swisshelm K.L., Gene 226:285-295(1999).Halford S., Cytogenet. Cell Genet. 88:217-217(2000).Kraemer F., Hum. Genet. 107:249-256(2000).

Description

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.Swisshelm K.L., Gene 226:285-295(1999).Halford S., Cytogenet. Cell Genet. 88:217-217(2000).Kraemer F., Hum. Genet. 107:249-256(2000).

Specification
Aliases	CLD1; CLDN1; SEMP1; Senescence-associated epithelial membrane protein; UNQ481/PRO944
Entrez GeneID	9076;
Swissprot	O95832
WB Predicted band size	30kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human Claudin 1 around the phosphorylation site of tyrosine 210 (G-K-D-Y(p)-V).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000

	Western blot analysis of extracts from HeLa cells, treated with Hu (2nM, 24hours), using Claudin 1 (Ab-210) antibody P41749.
	Western blot analysis of extracts from JK cells (Lane 2), using Claudin 1 (Ab-210) antiobdy P41749. The lane on the left is treated with synthesized peptide.