Rabbit Polyclonal Antibody to Claudin 1

包装: 1G|100G|500G|1KG|100KG

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别名:CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein
应用:WB,IHC,ICC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer. Claudin-1 is expressed primarily in keratinocytes and normal mammary epithelial cells, but is absent or reduced in breast carcinomas and breast cancer cell lines.

Description

The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer. Claudin-1 is expressed primarily in keratinocytes and normal mammary epithelial cells, but is absent or reduced in breast carcinomas and breast cancer cell lines.

Specification
Aliases	CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein
Entrez GeneID	9076
Swissprot	O95832
WB Predicted band size	Calculated MW: 23 kDa; Observed MW: 23 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	The antiserum was produced against synthesized peptide derived from human Claudin 1. AA range:162-211
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200
ELISA	1/10000

	Western blot analysis of Claudin 1 in Hela lysates using Claudin 1 antibody.
	Western blot analysis of Claudin 1 in HeLa lysates using Claudin 1 antibody. The lane on the right is blocked with the synthesized peptide.
	Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue, using Claudin 1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.
	Immunohistochemistry analysis of paraffin-embedded Mouse Colon tissue, using Claudin 1 antibody.High-pressure and temperature Tris-EDTA pH 9.0 was used for antigen retrieval.
	Immunohistochemistry analysis of paraffin-embedded Mouse Colon tissue, using Claudin 1 antibody.High-pressure and temperature Tris-EDTA pH 9.0 was used for antigen retrieval.