Rabbit Polyclonal Antibody to CLDN7

包装: 1G|100G|500G|1KG|100KG

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别名:Claudin-7, CLDN-7, CLDN7, CEPTRL2, CPETRL2
应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.

Description

This gene encodes a member of the claudin family. Claudins
are integral membrane proteins and components of tight junction
strands. Tight junction strands serve as a physical barrier to
prevent solutes and water from passing freely through the
paracellular space between epithelial or endothelial cell sheets,
and also play critical roles in maintaining cell polarity and
signal transductions. Differential expression of this gene has been
observed in different types of malignancies, including breast
cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors,
prostate cancer, lung cancer, head and neck cancers, thyroid
carcinomas, etc.. Alternatively spliced transcript variants
encoding different isoforms have been found.

Specification
Aliases	Claudin-7, CLDN-7, CLDN7, CEPTRL2, CPETRL2
Entrez GeneID	1366
Swissprot	O95471
WB Predicted band size	22.4kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This CLDN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-201 amino acids from the C-terminal region of human CLDN7.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
FCM	1/10-1/50

	CLDN7 Antibody (C-term) (Cat. #P30734) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CLDN7 antibody detected the CLDN7 protein (arrow).
	CLDN7 Antibody (C-term) (Cat. #P30734) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	CLDN7 antibody (C-term) (Cat. #P30734) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CLDN7 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.